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DALK improves vision in eyes with Acanthamoeba keratitis scarring

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CHICAGO – Deep anterior lamellar keratoplasty showed promise in restoring vision in eyes with significant corneal scarring from Acanthamoeba keratitis, a speaker said here.

DALK should be considered early as a treatment option in cases with active, resistant infection that are unresponsive to medical treatment, Caterina Sarnicola, MD, said at the American Academy of Ophthalmology meeting.

“DALK seems to a very good procedure for Acanthamoeba infection, active and non-active, even if a larger series of patients is required to evaluate the success rate and possible other complications,” Sarnicola said.

The study included 12 eyes of 12 patients with Acanthamoeba keratitis. Nine eyes had controlled infection and three eyes had active infection that was nonresponsive.

Eyes underwent medical treatment that involved 10 days of therapy with chlorexidine gluconate, propamidine isethionate and neomycin sulfate. Follow-up was 2 years.

Study results showed no Descemet’s ruptures, graft rejection, recurrent infection or secondary complications.

Average best corrected visual acuity was 17/20; BCVA was 20/20 in some eyes, Sarnicola said.

Disclosure: Sarnicola has no relevant financial disclosures.