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Hypotonic eye drops improved tear film stability, ocular surface integrity
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Application of hypotonic 0.18% sodium hyaluronate eye drops improved tear film stability and ocular surface integrity in patients with dry eye compared with the use of isotonic 0.1% sodium hyaluronate eye drops, according to results of a study.
The study included 60 patients with dry eye disease who were separated into four groups depending on whether they had level one or two dry eye disease. Patients with level one dry eye were treated with either preservative-free isotonic 0.1% sodium hyaluronate (SH) eye drops (group one) or preservative-free hypotonic 0.18% SH eye drops (group two). Patients with level two dry eye were treated with 0.1% fluorometholone, 0.05% cyclosporine A, and either isotonic 0.1% SH (group three) or hypotonic 0.18% SH eye drops (group four).
The researchers recorded patients’ tear film breakup time (TBUT), Schirmer test, corneal staining with fluorescein and ocular surface disease index score and baseline and again at 1 and 3 months after treatment.
Patients in group two had significant improvements in TBUT at 3 months and corneal staining scores at both 1 and 3 months compared with baseline, but patients in group one had no changes in either of these measures throughout the follow-up period, according to the researchers.
Among the patients in groups three and four, significant improvements were observed in TBUT and corneal staining scores at 1 and 3 months, and ocular surface disease index score and Schirmer test results at 3 months compared with the baseline scores. However, patients in group four had extended TBUT and improved staining scores at 3 months compared with group three patients.
Disclosure: The authors have no relevant financial disclosures.
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