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Extraocular cytomegalovirus infection linked to increased morbidity, mortality
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SAN DIEGO — Incidence of mortality and morbidity was significantly increased among patients with extraocular cytomegalovirus disease, according to a poster presented at the American Society of Retina Specialists annual meeting.
Nicola Y. Gan, MBBS, MMed (Ophth), and colleagues conducted a retrospective review of medical records for 101 patients diagnosed with cytomegalovirus (CMV) retinitis and HIV. Patients were categorized as having CMV retinitis only (73.3%) or extraocular CMV and CMV retinitis (26.7%). Primary outcome measures were mortality, CMV retinitis recurrence and development of immune-reactivation uveitis. Median follow-up time was 11.7 months.
Among patients in the CMV retinitis-only group, the mortality rate was 12.7 deaths per 100 person-years; in the group with concurrent extraocular CMV, the rate was 32.8 deaths per 100 person-years. Patients in the extraocular CMV group were found to have a shorter time to death.
Gan and colleagues also found greater bilateral involvement and larger CMV retinitis lesion size in patients with concurrent extraocular CMV disease.
No increase in CMV retinitis recurrence or immune-reactivation uveitis was associated with extraocular CMV disease; however, the risk of recurrence was significantly higher in eyes with immune-reactivation uveitis, according to the researchers.
Disclosure: Gan and colleagues have no relevant financial disclosures.