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SD-OCT predicts progression to geographic atrophy

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SAN DIEGO — Spectral-domain optical coherence tomography volume measurements of drusen and retinal pigment epithelium abnormal thinning may help stratify eyes with intermediate age-related macular degeneration to predict progression to advanced AMD.

Drusen volume as seen on spectral-domain OCT (SD-OCT) was able to predict progression to choroidal neovascularization, a speaker said here.

Sumit Sharma

Additionally, color fundus photography showing geographic atrophy area and SD-OCT showing retinal pigment epithelium abnormal thinning volume had similar ability to predict progression to central geographic atrophy.

In a study of 345 eyes with AMD, Sumit Sharma, MD, and colleagues found that every 0.05 mm³ in drusen increased the 2-year risk of choroidal neovascularization by 10% and every 0.1 mm³ in drusen increased the risk by 22%.

Future directions are to use the SD-OCT measurements of drusen and abnormal thinning to stratify eyes within category 3 to predict progression to advanced AMD, and also to use the biomarkers that we’ve developed to look at longer-term follow-up for both 5-year or 10-year risk of progression,” Sharma said.

Disclosure: Sharma has no relevant financial disclosures