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Less IOP fluctuation seen in patients with OAG and moderate-to-severe myopia
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Nocturnal IOP increased less in young myopic patients with open-angle glaucoma than in a control group of glaucoma patients with emmetropia or mild myopia, according to a study.
The prospective study included 108 patients with open-angle glaucoma (OAG) and moderate-to-severe myopia. The control group comprised 67 age-matched OAG patients with emmetropia or mild myopia. Mean patient age was 32.6 years in the study group and 33.8 years in the control group.
A handheld tonometer was used to record IOP 11 times over a 24-hour period; peak IOP time, or acrophase, and amplitude were recorded.
Mean habitual position IOP was significantly higher during sleeping hours than during waking hours in the control group (P < .001). No significant nocturnal spikes were seen in the myopia group.
In the study group, 44 patients (40.7%) had a diurnal acrophase, 17 (15.7%) had a nocturnal acrophase and 47 (43.6%) had no apparent acrophase.
In the control group, 14 patients (20.8%) had a diurnal acrophase, 30 (44.8%) had a nocturnal acrophase and 23 (34.4%) had no apparent acrophase.
Short- and long-term IOP changes induced by posture were significantly higher in the control group than in the myopia group (P < .01 for both).
Overall range of 24-hour IOP fluctuation was higher in the control group than in the study group but the difference was insignificant, the authors said.
Disclosure: The authors have no relevant financial disclosures.
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