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Study: Baseline focal loss volume seen on OCT predictive of conversion to perimetric glaucoma
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WASHINGTON — The most important predictor of conversion of preperimetric eyes to perimetric glaucoma seen on optical coherence tomography in one study was focal loss volume in the ganglion cell complex, a presenter said here.
“The goal of this substudy is to use Fourier-domain OCT (FD-OCT) to guide the initial treatment of patients at risk for losing visual field from primary open-angle glaucoma,” David Huang, MD, PhD, told colleagues at the American Glaucoma Society meeting.
In this substudy of the Advanced Imaging for Glaucoma Study, 55 eyes of 513 preperimetric eyes converted to perimetric glaucoma. Subjects were followed for a median of 52 months and were assessed at 6-month intervals.
David Huang
In Kaplan-Meier analysis, survival curves showed the focal loss volume in the ganglion cell complex was highly predictive at 6 years, Huang said.
FD-OCT measurements at the baseline visit are statistically significant predictors of future visual field conversion, presenting four times the risk for conversion if measurements are abnormal at baseline, Huang said.
“I think the reason [ganglion cell complex focal loss volume] is most significant is because it is a focal loss measure that is hard to fake from any other disease,” Huang said, because people with focal loss have ganglion cell damage that goes on to vision field loss.
Disclosure: Huang has a financial interest in the optical coherence tomography technology related to Optovue and Carl Zeiss Meditec.