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DSEK may be option in children with congenital hereditary endothelial dystrophy
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Descemet’s stripping endothelial keratoplasty can be an alternative to penetrating keratoplasty in children with congenital hereditary endothelial dystrophy, offering early visual stabilization and a low risk of complications.
In the retrospective, comparative, interventional study, five patients had a mean age of 6.6 years and underwent PK in one eye and DSEK in the fellow eye.
All grafts were clear at 1 year, and no significant difference in the spherical component of refraction was reported; however, eyes that underwent DSEK had a significantly lower rate of astigmatism.
All eyes had improved visual acuity.
By 6 weeks, refractive error was stabilized in most DSEK eyes, while refractive error continued to change in PK eyes for almost 1 year.
Graft dislocation occurred in two DSEK cases that were treated with re-bubbling, while graft dehiscence occurred in one PK case, which was treated with re-suturing.
DSEK offers lower levels of refractive astigmatism and lower risk of allograft rejection and long-term use of corticosteroids, while avoiding the risk of suture-related infections, the study authors said.
Disclosure: The study was funded by Hyderabad Eye Research Foundation, Hyderabad, India.
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