October 28, 2013
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Incomplete visual rehabilitation may be identified after DMEK

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The causes of incomplete visual rehabilitation after Descemet’s membrane endothelial keratoplasty can usually be identified, contrary to the undefined low visual outcomes that may be associated with other endothelial keratoplasty methods, a study found.

“This may suggest that the apposition of an isolated [Descemet’s membrane] onto the recipient posterior stroma most probably provides the best optical performance of a transplanted cornea today,” the study authors said.

The retrospective study analyzed 178 eyes, of which 69 eyes had incomplete visual rehabilitation after DMEK; 40 eyes were classified as primarily patient-related, 21 eyes were classified as primarily graft-related and eight eyes were classified as combined patient- and graft-related.

The primary causes of unanticipated incomplete visual rehabilitation were unrecognized pre-existing ocular pathology or posterior segment disease in 19 eyes, clinically significant corneal irregularities or scarring in 14 eyes and partial graft detachment in 20 eyes.

Ten eyes experienced temporary or persistent monocular ghost images or diplopia, with contact lenses sometimes being required.

Disclosure: Melles is a consultant for D.O.R.C. The remaining authors have no relevant financial disclosures.