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SD-OCT pinpoints anatomic changes associated with geographic atrophy progression
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Specific morphologic changes detected with spectral-domain optical coherence tomography were associated with progression and severity of geographic atrophy in eyes with age-related macular degeneration, according to a study.
Changes identified on SD-OCT were linked to accelerated enlargement of atrophic lesions, larger lesion size and presence of multifocal lesions.
The retrospective study included 43 eyes of 43 patients with geographic atrophy associated with AMD who underwent SD-OCT and fundus autofluorescence imaging. Mean follow-up was 47.4 weeks.
Based on a square root scale, the mean enlargement rate was 0.27 mm/year in eyes with unifocal lesions and 0.42 mm/year in eyes with multifocal lesions; the difference was statistically significant (P = .022).
Outer retinal tabulations, irregular elevations of the retinal pigment epithelium/Bruch membrane complex in the atrophic area, and splitting of the retinal pigment epithelium/Bruch membrane complex at two junctional zone borders had significant associations with rapid lesion enlargement (P = .003, P < .001 and P = .02, respectively).
Disclosure: Jaffe is a consultant for Heidelberg Engineering. The remaining authors have no relevant financial disclosures.
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