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Study to focus on genetics of glaucoma in African-American subjects

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The National Eye Institute has awarded a 5-year $6.4 million grant for a study on the genetics of glaucoma in persons of African descent, according to a press release.

The study, ADAGES III: Contribution of genotype to glaucoma phenotype in African-Americans, will be led by Robert N. Weinreb, MD, chairman and distinguished professor of ophthalmology at the University of California, San Diego School of Medicine and an OSN Glaucoma Board Member.

The goal of the study is to identify glaucoma genes in a high-risk, minority population, particularly in subjects who have rapidly worsening vision, according to the release.

Weinreb and his team will attempt to identify relevant genes, develop predictive models for glaucoma diagnosis and progression, and discover new drug targets for therapies to reduce the visual impact of glaucoma blindness, the release said.

The study will obtain detailed phenotypes of more than 2,000 subjects, establish a repository, implement a data-coordinating center at UC San Diego and conduct comprehensive genetic studies.