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In vivo OCT images linked to postoperative histology of periocular basal cell carcinoma
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In vivo OCT imaging had a positive association with postoperative histology of periocular basal cell carcinoma of the eyelids, according to a study.
The prospective study included 15 patients with basal cell carcinoma who underwent VivoSight optical coherence tomography (Michelson Diagnostics) imaging following surgical excision.
The OCT horizontal margins correlated positively with histology (r = 0.8 and 0.66, x and y axes), according to the authors. Of the 15 patients, horizontal measurements were acquired in three and six patients (x and y axes, respectively).
A moderate association was found between the histological and OCT measurements of the deep margin (z axis, r = 0.43), and the vertical measurement of basal cell carcinoma depth was acquired in nine patients, the study authors said.
The histological features of basal cell carcinoma assessed and identifiable on OCT included lobular patterns (100%), dilated blood vessels in the upper dermis (80%), highly reflective margins of tumor lobules (100%) and thinning of the epidermis overlying lobular structures (100%).
Modification of the scanning probe design can possibly overcome horizontal margin measurement limitations, the authors said.
Disclosure: See the study for a full list of all authors’ relevant financial disclosures.
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