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AREDS2 OCT study shows hyperreflective foci as markers for AMD progression
Hyperreflective foci proliferation and migration may herald geographic atrophy and progression of age-related macular degeneration, according to the AREDS2 Ancillary SD-OCT Study.
Investigators gauged hyperreflective foci distribution and its relationship with AMD progression. Spectral-domain optical coherence tomography was used to identify hyperreflective foci.
The prospective study included 299 eyes of 299 patients with intermediate AMD who underwent SD-OCT imaging at baseline, 1 year and 2 years.
Investigators evaluated changes in horizontal and vertical distribution of hyperreflective foci in the macula to determine 2-year inner retinal hyperreflective foci migration.
Significant associations were observed between geographic atrophy at 2 years and presence of baseline hyperreflective foci, higher number of baseline hyperreflective foci and higher baseline axial distribution scores (all P < .001).
The number of eyes with any form of geographic atrophy in the 6-mm field increased significantly from baseline to 1 year and from 1 to 2 years; both increases were significant (P < .001).
Mean hyperreflective foci per eye increased significantly from baseline to 1 year and from 1 year to 2 years (both P < .001).