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Plaque radiotherapy effective in managing iris melanoma
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Plaque radiotherapy proved effective in managing patients with iris melanoma with a low risk for metastasis, according to a study.
The retrospective case series included 144 patients with iris melanoma; 58 patients had secondary glaucoma at baseline examination. Patients underwent plaque radiotherapy with iodine-125.
Plaque radiotherapy successfully controlled melanoma in 133 patients (92%). Eleven patients had recurrence and underwent repeat plaque radiotherapy, systemic chemotherapy or enucleation.
Even though there were no significant differences when comparing final visual acuity, metastasis and enucleation, iris melanoma patients with glaucoma had a statistically higher risk of developing a flat tumor with melanoma seeding compared with iris melanoma patients without glaucoma (66% vs. 43%, respectively).
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