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SD-OCT most sensitive, specific in detection of reticular pseudodrusen in AMD
Spectral domain optical coherence tomography showed the greatest sensitivity and specificity in identifying reticular pseudodrusen in age-related macular degeneration, according to a study.
The study included 220 eyes of 114 patients with AMD. All patients underwent imaging with blue channel image of color fundus photography, infrared reflectance, fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography and SD-OCT.
Thirty-seven eyes of 21 patients were diagnosed with reticular pseudodrusen. Mean age of the patients with reticular pseudodrusen was 80.4 years and mean age of those without reticular pseudodrusen was 72.3 years; the difference was statistically significant (P = .0002).
SD-OCT and infrared reflectance showed the highest sensitivity, at 94.6%; SD-OCT showed the highest specificity, at 98.4%.
Blue channel image of color fundus photography, confocal blue reflectance and indocyanine green angiography showed specificity of 100% but were less sensitive than SD-OCT and infrared reflectance, the authors said.