This article is more than 5 years old. Information may no longer be current.
OCT angiography may detect pre-perimetric changes in glaucomatous eyes
Click Here to Manage Email Alerts
WAIKOLOA, Hawaii — Optic nerve head microcirculation is reduced in glaucoma patients, a speaker said here.
“Conventionally, OCT is used to measure structure with micron precision, and that has been very useful in terms of characterizing the structure of the optic nerve head, the nerve fiber layer and the ganglion cell complex,” David Huang, MD, PhD, said at Hawaiian Eye 2013. “We developed a technique where we decomposed the OCT image into several spectral bands and analyzed them separately and recombined them to enhance a signal of flow.”
David Huang
In a pilot study chaired by Huang, 20 normal eyes of 20 subjects were compared with 10 glaucoma eyes of 10 subjects, including six perimetric glaucoma eyes, three pre-perimetric glaucoma eyes, and one eye suspected to have ocular hypertension.
The study found OCT angiography may detect pre-perimetric changes, as well as reduced optic nerve head microcirculation in glaucomatous eyes.
Optic nerve head flow index can be measured with 6.6% reproducibility and 1.1% repeatability, according to the study.
Disclosure: Huang receives royalties from Optovue and Carl zeiss Meditec, as well as grant support and speaker honorarium from Optovue.