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Single-dose antibiotic preparation shows safety and efficacy in large series of cataract patients
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PARIS — Sterile, single-dose cefuroxime 50 mg powder for solution for injection is safe and well-tolerated in complicated cataract cases and might prove to be indicated for other anterior segment penetrating surgeries, according to a study.
At the meeting of the French Society of Ophthalmology, Loïc Bazin, MD, said that Aprokam (Laboratoires Théa) is "easy to preserve and to use, saves time and avoids potential batch contamination and dilution errors."
Cefuroxime used to be prepared for intracameral use in hospital pharmacies or in the operating theater and required two dilutions. The new preparation only needs a single dilution with 5 mL of sodium chloride 9 mg/mL (0.9%).
In a prospective study carried out at the University Hospital of Brest, France, 203 patients were injected with Aprokam during cataract surgery. Twelve had surgery complicated by capsular rupture. Clinical tolerance, infections and presence of macular edema were evaluated at 1 week postop.
"In the 9 months of our study, we have observed excellent tolerance with no case of endophthalmitis or [toxic anterior segment syndrome]. No sign of macular edema was found, also in the eyes where capsular rupture had occurred," Bazin said.
Results suggested that Aprokam could also be used in complicated cataract cases, in which concerns about the safety of intracameral cefuroxime had been raised.
Disclosure: Bazin has no relevant financial disclosures.