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OCT imaging enables creation of RNFL, macular thickness norms for children
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Optical coherence tomography images were used to generate measurement standards for macular thickness, peripapillary retinal nerve fiber layer thickness and retinal layer thickness in children, according to a study.
The prospective study included 83 healthy children aged 5 to 15 years. The Spectralis spectral domain OCT system (Heidelberg Engineering) was used to assess peripapillary retinal nerve fiber layer (RNFL) thickness and macular thickness in one eye of each child.
Investigators used custom computer software to establish average RNFL and macular thickness measurements based on segmentation of line scans captured with the OCT. They used statistical analysis to assess the impact of age, sex and race/ethnicity on thickness measurements.
Study results showed no significant influence of sex or race/ethnicity on central foveal subfield thickness. However, central foveal subfield thickness increased significantly with age (P = .032).
Similarly, there was no significant impact of sex or race/ethnicity on global peripapillary RNFL thickness. There was no change in global peripapillary RNFL thickness according to age.
The outer retinal segment layer was 36% thinner in children than in adults, the authors said.
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