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SD-OCT appropriate in evaluating foveal sparing in geographic atrophy
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Spectral domain optical coherence tomography, followed by blue light fundus autofluorescence and near-infrared fundus autofluorescence, is appropriate to evaluate foveal sparing in patients with geographic atrophy, according to a study.
The study included 158 eyes of 83 patients who had geographic atrophy due to age-related macular degeneration. They underwent blue light fundus autofluorescence, near-infrared fundus autofluorescence and SD-OCT scanning with the Spectralis HRA + OCT (Heidelberg Engineering).
Foveal involvement was evaluated for all eyes using the three imaging modalities.
Study results showed that SD-OCT demonstrated the highest intergrader agreement in identification of foveal involvement.
According to interobserver agreement, foveal sparing was found in 74 eyes. Width of the foveal sparing was greater when measured with SD-OCT (1,334 µm) than with near-infrared fundus autofluorescence (1,228 µm) and blue light fundus autofluorescence (1,201 µm); the differences were statistically significant (both P < .001).
Seventy-two of the 74 eyes with foveal sparing showed primarily central and stable retinal fixation.
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