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Successful trabeculectomy hinges on greater bleb area, reduced bleb vascularity
Eyes with greater central and maximal bleb area and reduced bleb vascularity had better surgical outcomes after trabeculectomy, according to a study.
The cross-sectional study evaluated bleb morphology in 85 eyes of 85 patients by slit lamp using the Moorfields Bleb Grading System. Conjunctival specimens were obtained to examine the expression of the inflammatory marker human leukocyte antigen-DR (HLA-DR).
Successful trabeculectomy was achieved in 58 of the eyes that had greater central and maximal bleb area (P < .001). These patients also showed reduced vascularity of the central part and peripheral part of the bleb, (P = .02 and P = .03, respectively).
No significant differences were found in the expression of HLA-DR on conjunctival epithelial and antigen-presenting cells between the eyes with successful and failed surgery.