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Ibopamine test elevates IOP in offspring of one parent with history of POAG
Ibopamine instillation increased IOP in subjects who had at least one parent with primary open-angle glaucoma, according to a study.
The study authors said this signifies “an impaired function of outflow structures and, therefore, a predisposition to intraocular hypertension and possible glaucoma.”
Investigators evaluated 163 offspring, who had normal IOP and no glaucoma damage, of at least one parent with primary open-angle glaucoma (POAG) and 108 offspring of parents with no history of glaucoma.
Both eyes of each subject received two drops of ibopamine administered 5 minutes apart. IOP measurements were repeated for 45 minutes. A test was deemed positive if IOP increased 3 mm Hg or more 45 minutes after administration.
Study results showed positive tests in 44.33% of subjects in the POAG offspring group; IOP increased a mean 5.57 mm Hg, which was statistically significant (P < .001).
All subjects in the non-POAG group had negative tests.