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RNFL changes portend glaucomatous visual field progression
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Structural morphology correlated significantly with functional loss in patients with glaucoma and suspected glaucoma, according to a study.
The prospective clinical trial included 310 glaucoma suspect and preperimetric eyes and 177 perimetric eyes that underwent time-domain optical coherence tomography and standard automated perimetry at 6-month intervals. Average peripapillary retinal nerve fiber layer (RNFL) thickness, superior quadrant thickness and inferior quadrant thickness were measured.
Glaucoma progression was defined as a significant downward slope in visual field index scores and RNFL thickness. Improvement was defined as a significant upward curve in visual field index scores and RNFL thickness.
Study results showed visual field progression in 89 eyes and RNFL progression in 101 eyes.
The average time to identify progression was 35 months for visual field loss and 36 months for RNFL loss.
Average RNFL thickness was 76.44 µm in perimetric glaucoma patients and 92.74 µm in glaucoma suspect or preperimetric patients (P < .001).
Data showed that mean IOP was 14.7 mm Hg in perimetric glaucoma patients and 16.86 mm Hg in glaucoma suspect and preperimetric glaucoma patients; the difference was significant (P < .001).
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