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Oral antibiotic beneficial in treatment of meibomian gland dysfunction
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Oral minocycline reduced inflammatory cytokine levels in patients with moderate or severe meibomian gland dysfunction, a study determined.
The prospective clinical trial examined 60 eyes of 60 patients with stage 3 or 4 meibomian gland dysfunction.
Subjects were randomly divided into two groups. One group received oral minocycline and artificial tears for 2 months, while the other received artificial tears only for 2 months.
Tear film breakup time, Schirmer test results, corneal and conjunctival fluorescein staining results, biomicroscopic examination of lid margins and meibomian glands, and tear cytokine levels were evaluated in all patients at baseline and at 1 month and 2 months after treatment.
Patients who used minocycline had a statistically significant improvement compared with the control group in tear film breakup time (P = .014), corneal fluorescein staining score (P = .005), lid margin abnormality (P < .001) and meibum quality (P < .001) after 2 months.
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