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Choroidal thickness reduced in acute VKH disease following steroid regimen
A high-dose corticosteroid treatment reduced choroidal thickness in some patients with Vogt-Koyanagi-Harada disease, according to a study.
The retrospective review examined 16 eyes in 8 patients with acute Vogt-Koyanagi-Harada (VKH) disease.
Standard optical coherence tomography (OCT) and enhanced depth imaging OCT (EDI-OCT) were used to evaluate choroidal thickness before and after the start of a high-dose corticosteroid treatment regimen.
All patients were initially treated with a single intravenous pulse of 1,000 mg/day methyl prednisolone for 3 consecutive days.
Compared with choroidal thickness at 1 week of follow-up, mean choroidal thickness at 1 month of follow-up was statistically significantly reduced in all eyes (P = .0012). Mean choroidal thickness remained stable in all eyes at 3, 6, 9 and 12 months of follow-up.
At 1 week following treatment initiation, eyes with a choroidal thickness of greater than 550 µm were associated with the development of peripapillary atrophy at 6 months and 12 months after treatment (P = .0003).