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Infectious keratitis after keratoprosthesis implantation can occur despite prophylaxis
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Patients may develop infectious keratitis after implantation of a Boston type 1 keratoprosthesis even with the use of vancomycin and a fourth-generation fluoroquinolone for prophylaxis, a study found.
The retrospective chart review included 126 eyes of 105 patients who underwent KPro implantation and were followed for a mean of 25 months postoperatively.
Ten cases (7.9%) had infectious keratitis after implantation.
All patients with keratitis were using topical vancomycin and moxifloxacin, and two were using topical amphotericin. Topical agents were used to manage all the patients, and an oral antifungal agent was used in four patients.
A diagnosis of cicatrizing conjunctivitis was found to be a risk factor for infectious keratitis (P = .0003), as was a history of persistent epithelial defect (P = .0142). Contact lens wear, vancomycin use, and a history of systemic immunosuppression use were not determined to be statistically significant risk factors for keratitis.
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