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Glaucoma study links rising IOP, increasing central corneal thickness
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Changes in central corneal thickness influenced IOP measurements in a Nepalese population, a large study found.
“The changes in central corneal thickness values cause a significant variation in intraocular pressure in this population, suggesting that measurement of central corneal thickness will have implications in the diagnosis and management of glaucoma,” the study authors said.
Data were culled from the Bhaktapur Glaucoma Study, a population-based analysis designed to gauge the prevalence of glaucoma among adults aged 40 years and older from the Bhaktapur district of Nepal.
The study included 2,330 subjects with a mean age of 51.3 years who had no history of glaucoma, corneal pathology or previous intraocular surgery.
All subjects underwent a complete ophthalmic examination that included ultrasonic pachymetry and Goldmann applanation tonometry.
Study results showed mean central corneal thickness of 539.1 µm and mean IOP of 13.33 mm Hg. Central corneal thickness diminished an average of 2.67 µm with each decade of age.
IOP varied significantly with age among male subjects (P < .001). IOP variations were most significant in men aged 40 to 49 years vs. 60 to 69 years (P = .002) and 40 to 49 years vs. 70 years or older (P = .01).
Data adjusted for age and gender showed a 100-µm increase in central corneal thickness correlating with a 1.03-mm Hg rise in IOP, the authors said.
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