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Several measurements may be useful in predicting visual field progression
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Baseline stereophotography, optical coherence tomography and confocal scanning laser ophthalmoscopy may play a role in predicting glaucomatous visual field progression, according to a study.
“Comparing the single best parameter from all models, only the OCT superior quadrant [retinal nerve fiber layer] predicted progression,” the study authors said.
The retrospective study included 119 eyes of 70 subjects. Forty-four eyes were glaucomatous, 57 were glaucoma suspects and 18 were healthy.
Inclusion criteria were best corrected visual acuity of 20/60 or better and refractive error of +6 D to –6 D.
Five or more baseline optic nerve stereophotographs, OCT and confocal scanning laser ophthalmoscopy images were obtained for all eyes with the Nidek 3-Dx, Stratus OCT (Carl Zeiss Meditec) and Heidelberg Retina Tomography (Heidelberg Engineering). All eyes underwent visual field testing with the Humphrey Field Analyzer (Carl Zeiss Meditec).
Median visual field follow-up was 4 years.
Study results showed that 15 eyes progressed by glaucoma progression analysis, 20 by visual field index and 10 by both measures.
Overall, the most significant predictors of glaucoma progression analysis were baseline stereophotography (vertical cup-to-disc ratio and likelihood of disc damage), OCT (global, superior quadrant and inferior quadrant retinal nerve fiber layer thickness) and confocal scanning laser ophthalmoscopy (cup shape measure and mean cup depth).
The most significant predictors of visual field index progression were OCT superior quadrant retinal nerve fiber layer, vertical cup-to-disc ratio on stereophotography and mean cup depth on confocal scanning laser ophthalmoscopy, the authors said.
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Ophthalmic Surg Lasers Imaging. 2012;43(5):416-424.
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