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Optic nerve head characteristics differ between keratoconus, healthy subjects
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Optic nerve head characteristics are significantly different between patients with non-glaucomatous keratoconus and healthy control subjects, but retinal nerve fiber layer thickness measurements are more comparable, according to a study.
The prospective, observational, cross-sectional study examined 46 patients with keratoconus and 74 healthy subjects. Confocal scanning laser ophthalmoscopy was used to analyze the optic nerve head, and optical coherence tomography was use to analyze the retinal nerve fiber layer.
Eyes with keratoconus had significantly larger disc area than the healthy eyes (P = .013), larger cup area (P = .035) and deeper cup depths (mean cup depth, P = .008; maximum cup depth, P = .037).
There was a significant difference in height variation contour between the groups (P = .007), but there were no significant differences for retinal nerve fiber layer measurements.
“The results of this study suggest that optic disc parameters may have a relationship with corneal hysteresis,” the study authors said. “Further longitudinal studies with a larger sample size are needed to elucidate the relationship between keratoconus and development of glaucoma.”
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