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Biomarker profiling may predict postoperative PVR development
Biomarker profiling may help predict postoperative proliferative vitreoretinopathy development after rhegmatogenous retinal detachment, according to a study.
The retrospective review analyzed biomarker samples from 21 patients who had a re-detachment develop as a result of proliferative vitreoretinopathy (PVR). The samples were compared with 54 age-, sex- and storage time-matched samples from patients with an uncomplicated postoperative period after primary rhegmatogenous retinal detachment (RRD) repair.
Measurements were taken in all patients regarding the size of retinal detachment, number of retinal defects, macular detachment, detachment duration and preoperative PVR grade. All biomarkers were measured in subretinal fluid samples taken during scleral buckling surgery for primary RRD.
Fifty biomarkers were tested, and 18 of those were significantly different between the PVR and RRD groups. Preoperative PVR was the single clinical variable that independently predicted postoperative PVR development (P = .035).
“We conclude that biomarker profiling, in combination with the assessment of preoperative PVR status, may distinguish patients at high risk of developing PVR from those who have an uncomplicated postoperative course in a highly sensitive and specific manner,” the study authors said.