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CATT analysis finds intraretinal fluid greatest influence on visual acuity
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LAS VEGAS — The main drivers for treatment in the CATT based on optical coherence tomography and fluorescein angiography were the presence of fluid — intraretinal, subretinal or subretinal pigment epithelium — but the driver of visual acuity is intraretinal fluid, a speaker said here.
“Lucentis [ranibizumab, Genentech] monthly best decreases all types of fluid,” Glenn J. Jaffe, MD, said at the American Society of Retina Specialists meeting. He explored retinal morphology in association with visual acuity in the 2-year data from the Comparison of Age-related Macular Degeneration Treatment Trials.
Glenn J. Jaffe
As expected, eyes with any fluid had a little worse vision, Jaffe said, but the differences were not great, regardless of time point, with foveal fluid having about a three-letter worse visual acuity than no fluid.
“The driver was really intraretinal fluid, or cysts,” he said. “Here we saw big differences, and this occurred at every time point, both at baseline and at every time point up to week 52.”
With no fluid, visual acuity was about 70 letters, but eyes with foveal intraretinal fluid or cysts had about a two-line decrease at all time points, Jaffe said.
“As you get out to the late time points, the amounts of fluid are very small, so essentially there wasn’t a lot of difference with subretinal fluid or sub-RPE fluid. … The finding of fluid and how to interpret the fluid has helped to guide my treatment of these patients,” he said.
Disclosure: Jaffe has no relevant financial disclosures.