April 05, 2012
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Study links elevated episcleral venous pressure, Sturge-Weber syndrome glaucoma

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Elevated episcleral venous pressure has a significant effect on the development and progression of Sturge-Weber syndrome glaucoma in pediatric patients, according to a study.

“Our data support the hypothesis that elevated [episcleral venous pressure] plays an important role in [Sturge-Weber syndrome],” the study authors said.

The prospective analysis included 22 eyes of 11 patients aged 8 years to 18 years with Sturge-Weber syndrome with or without glaucoma.

An episcleral venomanometer was used to gauge episcleral venous pressure (EVP) in glaucomatous eyes of patients with Sturge-Weber syndrome. Measurements were compared to those of patients with facial port wine marks but no glaucoma and to those for fellow eyes in both groups.

Study results showed that mean EVP was 20.9 mm Hg in glaucomatous eyes and 9.6 mm Hg in uninvolved fellow eyes. The between-group difference was statistically significant (P < .01).

Among patients with unilateral port wine marks and no glaucoma, mean EVP was 8.6 mm Hg in ipsilateral eyes and 9.6 mm Hg in contralateral eyes. Both EVP measurements were within the normal range, the authors said.