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Visual acuity improves more in patients given loading dose of anti-VEGF

Br J Ophthalmol. 2008;92:1606-1611.

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Mean visual acuity improved significantly by 13.7 letters at 6 months of follow-up in patients with choroidal neovascularization secondary to AMD who were given a loading dose of bevacizumab once a month for 3 months and thereafter as needed.

In a prospective study of 50 patients, 25 patients were given the loading dose treatment and 25 patients were given Avastin (bevacizumab, Genentech) on an as-needed basis. In the as-needed group, patients gained a mean of 4.6 letters (P < .001) at 6 months.

A significant decrease in foveal thickness occurred in both groups, with mean foveal thickness decreasing by 91.3 µm (P < .001) in the loading dose group and by 48.2 µm (P < .001) in the as-needed group.

According to the study authors, an optimal time interval between two injections has not yet been determined.

There were no relevant ocular or systemic side effects in either group.