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VEGF, endostatin correlated with angiogenesis in DR, study finds
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TOKYO — Both vascular endothelial growth factor and endostatin are correlated with the severity of diabetic retinopathy, according to a study here. The mechanisms of these substances may be good candidates for development of therapeutic agents for proliferative diabetic retinopathy, the study authors suggest.
Researchers here studied 159 eyes of 120 patients with diabetes to determine concentrations of vascular endothelial growth factor (VEGF) and endostatin in vitreous fluid and aqueous humor.
The concentrations of VEGF in aqueous humor and vitreous fluid were significantly correlated with the severity of diabetic retinopathy (DR), as were the concentrations of endostatin in aqueous humor and vitreous fluid. Concentrations of VEGF and endostatin in the eyes were not correlated with those in the plasma.
The study is published in the August issue of Archives of Ophthalmology.