March 23, 2005
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Translocation may offer viable option for AMD

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LONDON — A two-part surgery to move healthy retina away from a diseased spot and then rotate the entire retina back into focal range may be a viable alternative for patients with age-related macular degeneration, said one researcher here.

Lyndon da Cruz, FRACO, FRCOphth, PhD, of Moorfields Eye Hospital said in one case study translocation surgery improved visual acuity from 6/60 preoperatively to 6/12 postoperatively. He spoke at the Moorfields Bicentenary scientific meeting.

“This is a complex surgery,” he said. A review of the literature indicated “about half to one-third regain ‘significant’ vision,” he said. About 20% develop proliferative vitreoretinopathy or other complications, he added.

“Translocation surgery has been performed for wet and dry AMD, retinal pigment epithelium tears and angioid streaks,” among others, he said. He said he hopes a larger-scale trial on translocation for the treatment of both forms of AMD will begin soon.