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Topical phenytoin potentially effective against refractory corneal ulcers
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LAS VEGAS — Topically phenytoin powder may be an effective treatment for non-healing corneal ulcers, according to a study presented here.
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Jasvir Singh Grewal, MBBS, discussed the results of a randomized, prospective study including 60 patients with corneal ulcers at the American Academy of Ophthalmology meeting. All patient had been unresponsive to standard treatment, he said.
Of the 60 patients in the study, 30 received 15 days of treatment with topical phenytoin powder and bandages. The other 30 patients received bandages alone and served as a control group.
The researchers found that 86.7% of phenytoin-treated patients achieved complete pain relief and healing compared to 48% of control patients.
Mr. Grewal noted that he used phenytoin powder due to limited availability, and that phenytoin gels or solutions should be investigated.