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Topical NSAID effective on chronic CME

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A topical nonsteroidal anti-inflammatory drug had a positive effect on chronic cystoid macular edema, but the effect of NSAIDs on acute CME warrants further study, according to a literature review.

S. Sivaprasad and colleagues reviewed the data from seven clinical trials that involved 266 participants to determine the effectiveness of NSAIDs in the treatment of CME after cataract surgery. Four trials studied chronic CME, and three focused on acute CME. While one study enrolled 120 participants, the remainder had 34 or fewer participants. Four different NSAIDs were used and administered.

Indomethacin was used orally and found ineffective in the treatment of chronic CME in one trial; topical fenoprofen was also found ineffective for chronic CME. Topical 0.5% ketorolac was found effective for the treatment of chronic CME in two studies. A meta-analysis of the three trials on acute CME was not possible because study designs differed and the NSAIDs studied were compared with placebo, prednisolone or another NSAID.

The review is published in The Cochrane Library.