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Topical NSAID effective for inflammation in glaucoma, study shows
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A nonsteroidal anti-inflammatory drug is as effective as a steroid for reducing inflammation prior to filtering surgery, and it may be better tolerated, a multicenter French study indicates.
Preservative-free indomethacin was as effective as preserved fluorometholone in reducing subclinical conjunctival inflammation induced by glaucoma medications, the study found.
Christophe Baudouin, MD, and colleagues performed a randomized, multicenter study on 49 patients comparing the safety and efficacy of indomethacin 0.1%, a topical NSAID, to fluorometholone 0.1%, in reducing subclinical conjunctival inflammation following use of antiglaucoma drugs. The solutions were administered four times a day for 30 days. Normal glaucoma therapy was continued during the study.
Conjunctival inflammation was graded by the percentage of cells expressing HLA-DR and specimens were available at baseline and on day 30.
No significant difference was seen between the groups.
The authors note the cornea may also better tolerate indomethacin than fluorometholone. Six cases of superficial punctate keratitis were observed in the fluorometholone group on day 30. Only one case was observed in the indomethacin group.
The report was published in November issue of Graefe's Archive for Clinical and Investigative Ophthalmology.