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Topical levofloxacin better penetrated into the vitreous than ofloxacin, study found

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Levofloxacin yielded 2.5 times higher vitreal concentration than ofloxacin when applied in equal doses, a small prospective study found.

Tuomo Puustjärvi, MD, of Kuopio University Hospital in Finland, and colleagues randomized 16 patients undergoing vitrectomy to receive either topical ofloxacin 0.3% or levofloxacin 0.5%. Each patient received four doses on the day before surgery and four doses at 1 hour preop.

The researchers found that an equal dose of levofloxacin resulted in 2.5 times higher vitreal concentration compared to ofloxacin, having a mean concentration of 13.09 ng/mL vs. 5.3 ng/mL for ofloxacin (P = .002), according to the study authors.

"The levels of mean concentrations of each drug did not exceed the MIC(90) or MIC(50) for most ocular pathogenic bacteria in terms of conventional endophthalmitis therapy," the authors noted.

The study is published in the December issue of Graefe's Archive for Clinical and Experimental Ophthalmology.