August 21, 2008
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Topical cyclosporine shows best results for treating mild dry eye disease, study finds

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Topical cyclosporine appears to show benefit for patients with mild, moderate and severe dry eye disease who are unresponsive to artificial tears, a prospective study suggests.

Henry D. Perry, MD, and colleagues evaluated the use of Restasis (topical cyclosporine 0.05%, Allergan) in 62 patients with mild dry eye disease, 69 patients with moderate disease and 27 patients with severe disease.

Follow-up ranged from 3 to 16 months.

The investigators observed improvement in 46 patients (74.1%) with mild dry eye disease, 50 patients with moderate disease (72.4%) and 18 patients with severe disease (66.7%), for an overall improvement of 72.1%.

"The increased benefits of treatment in the mild group suggest that early treatment of dry eye disease may yield the best results," the authors said in the August issue of Archives of Ophthalmology.