This article is more than 5 years old. Information may no longer be current.
Topical cyclosporine A efficacious in treatment of severe trachomatous dry eye
Clin Experiment Ophthalmol. 2009;37(6):541-549.
Click Here to Manage Email Alerts
Topical cyclosporine A treated severe trachomatous dry eye, with statistically significant different results in multiple test scores after 6 months of treatment, a study found.
"Topical [cyclosporine A] was effective in the treatment of severe trachomatous dry eye, yielding improvements in both objective and subjective measurements with a safety profile," the researchers said.
The study looked at results of 64 patients with severe trachomatous dry eye. Of those, 32 patients were treated twice daily with topical cyclosporine A 0.05% ophthalmic emulsion and five time daily with non-preserved artificial tear; the other 32 served as a control group, twice daily receiving a vehicle emulsion and five time daily receiving a non-preserved artificial tear. Follow-up was 6 months.
Researchers found that topical cyclosporine A treatment had statistically significant differences in test results before and after treatment for total symptoms, ocular surface disease index, rose Bengal and fluorescein staining.
Results were also statistically significantly different for tear film breakup time values and Schirmer testing measurements.