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Tissue glue effective for treating corneal perforations

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Isobutyl cyanoacrylate tissue adhesive is “highly effective” for treating corneal perforations, according to a retrospective study. About half of perforations of 3 mm or less in the study healed, and visual acuity improved in those patients as well.

Daria E. Setlik, MD, and colleagues at Duke University Medical Center reviewed the charts of 22 eyes of 20 patients whose corneal perforations of 3 mm or less in size were treated with isobutyl cyanoacrylate tissue adhesive.

Nine of the 22 eyes (40.9%) healed with the application of the adhesive alone. The mean interval of healing time was 33.4 days. Of those nine eyes, visual acuity improved in seven (77.8%) and remained stable in two. Seven eyes (31.8%) proceeded to penetrating keratoplasty. In those eyes, visual acuity improved in five, remained stable in one and decreased in one. Six eyes required more than one application of adhesive.

The study is published in the American Journal of Ophthalmology.