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Timolol gum compares well to timolol gel
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CHARLESTON, S.C. — Timolol maleate in xanthan gum was similar in most respects to timolol in a gel forming solution in a comparison study here. At 8 hours after dosing, the gum preparation lowered intraocular pressure more than the gel forming solution, the study found.
Following a washout period, 28 patients with primary open-angle glaucoma and ocular hypertension were randomly assigned to receive either timolol maleate 0.5% in xanthan gum or timolol maleate 0.5% gel forming solution. The drug was administered once each morning for 6 weeks, and patients were then crossed over to the opposite medicine for a similar time.
The diurnal IOP, the IOP at trough and the IOP at 2 hours after dosing were statistically equal between the groups. Eight hours after dosing, the mean pressure was 17.5 mm Hg in the gum group and 18.9 mm Hg in the gel group. Safety was similar between the groups.
The study is published in Current Eye Research.