Subretinal precipitates, other factors affect women’s recovery from CSC

MILWAUKEE, Wis. — Women with subretinal precipitates were nearly 18 times more likely to achieve complete recovery from central serous chorioretinopathy than women without subretinal precipitates, according to large study here. In addition, women without subretinal precipitates were more likely to have final visual acuity of less than 20/40, the study authors said.

Researchers here retrospectively studied 84 eyes of 78 women with central serous chorioretinopathy (CSC). Fifty-two eyes (62%) achieved complete recovery over a median of 5 months, and 88% had final vision of 20/40 or better.

Women with CSC associated with subretinal precipitates, shorter duration, single occurrence, lack of hormone replacement therapy use and absence of pigment epithelial detachment (all statistically significant) were more likely to achieve complete recovery than women who did not have those characteristics. In older women and those with pigment epithelial detachment, CSC was more likely to take longer to resolve.

Recurrence of CSC and lack of subretinal precipitates (P = .03) were statistically significantly associated with a final vision of less than 20/40. Age older than 50 years (P = .004) and presence of pigment epithelial detachment (P = .02) were associated with a longer duration of CSC.

The study is published in the February issue of Ophthalmology.