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Study: Vigabatrin affects retinal function earlier rather than later

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Infants on vigabatrin show signs of early photopic pathway disruptions more than late disruption, according to a study.

Sharon Morong and colleagues at the Hospital for Sick Children in Toronto studied photopic electroretinograms (ERGs) of 26 infants who had been placed on vigabatrin for infantile spasm. The infants ranged in age from 1.5 to 24 months; the number of visits ranged from two to four. Eighteen of the infants were assessed before beginning treatment, and eight were assessed within 1 week of starting vigabatrin therapy. ERGs were recorded at 6-month intervals.

Early oscillatory potentials (OPs) showed significant decrease after 6 months and remained decreased for the duration of treatment. No significant change was seen in late OPs.

The study is published in the November issue of Documenta Ophthalmologica.