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Study touts benefits of intraoperative triamcinolone acetonide in vitrectomy

Graefes Arch Clin Exp Ophthalmol. 2009;247(9):1153-1163.

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Staining with triamcinolone acetonide can aid in visualization of vitreous during vitrectomy, and while complications can occur, they are generally manageable with topical treatment, according to a study.

Intraoperative use of triamcinolone acetonide has become commonplace in a wide variety of closed surgical settings, according to the study. It can highlight posterior hyaloid, preretinal membrane and the internal limiting membrane, which recent evidence suggests is important in the repair of macular hole.

Use of triamcinolone acetonide was associated with a reduction of intraoperative retinal breaks and retinal detachments compared with traditional vitrectomy in a prospective, controlled trial. Prominent complications during the surgeries included transient IOP elevation, occurring in about 5% of cases. However, most cases were manageable with topical treatment.

Incidence of acute endophthalmitis was 0.03% to 0.05%, which is comparable to standard vitrectomy without triamcinolone acetonide, the study authors said.