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Study shows independent link between angle closure, lens vault
Ophthalmology. 2011;118(3):474-479.
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Angle closure was associated with lens thickness, lens vault, shallow anterior chamber depth and shorter axial length in a group of Chinese patients, a study found.
"Lens vault was associated strongly and independently with angle closure and distinguished eyes with angle closure from those with open angles better than traditional biometric parameters," they said. "Lens vault therefore is a potential novel marker associated with angle closure."
The prospective study included 102 patients with angle closure and 176 controls with open angles and no signs of glaucoma. Patients with angle closure were a mean 65.3 years old and controls were a mean 54.2 years old.
Patients underwent gonioscopy, anterior segment optical coherence tomography and slit lamp examination. Customized software was used to gauge lens vault. A-scan biometry was used to measure lens thickness, lens position and relative lens position. Visual acuity and IOP were also assessed. Primary outcome measures were lens parameters and angle closure.
Angle closure patients had mean lens vault of 901 µm, lens thickness of 4.2 mm, ratio of lens thickness to axial length of 0.18, anterior chamber depth of 2.66 mm and axial length of 22.86 mm.
Controls had mean lens vault of 316 µm, lens thickness of 3.9 mm, lens thickness to axial length ratio of 0.16, anterior chamber depth of 2.95 mm and axial length of 23.92 mm.
All between-group differences were statistically significant. Differences in lens position and relative lens position were insignificant.