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Study: posterior capsular folds affected by IOL choice

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LONDON — Haptic compressibility affected lens epithelial cell growth in a randomized prospective study here. PMMA IOLs produced less lens epithelial cell growth in the direction of posterior capsule folds than hydrogel IOLs, according to the study, published in the Journal of Cataract & Refractive Surgery.

William Meacock, FRCOphth, and colleagues studied 60 patients who had standardized phacoemulsification with in-the-bag placement of a PMMA or hydrogel IOL.

Researchers measured IOL haptic compressibility in air and then during incubation in saline at 37° C over 1 month. The presence and duration of postop capsule folds were recorded and correlated with haptic compressibility measurements, lens epithelial cell growth patterns on the posterior capsule at 6 months, and the extent of posterior capsular opacification.

On the first postop day, 21 patients (88%) in the hydrogel group had posterior capsule folds that persisted in 12 patients for 2 years. Nineteen patients (68%) in the PMMA group had folds at day 1, with one patient having folds at 1 month, but no patients with folds at 3 months. At 6 months, 11 patients in the hydrogel group and no patient in the PMMA group had lens epithelial cell growth in the direction of the folds.