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Study: OCT correlates with histopathology, offers ‘noninvasive biopsy’
BERLIN — Optical coherence topography allows “noninvasive optical biopsy” of pathological structures in corneal diseases, a study here suggests.
Researchers used noncontact slit-lamp-adapted corneal optical coherence topography (OCT) to study six patients prior to penetrating keratoplasty. After keratoplasty, the patients’ corneal specimens were examined using light microscopy and histology. Three of the patients had pseudophakic bullous keratopathy, one had advanced keratoconus, one had persistent epithelial defect with corneal thinning and one had retrocorneal membrane.
Although the mean OCT thickness values were up to 9% higher than those derived by light microscopy, there was a significant correlation between corneal OCT and the light-microscopic measurements, the authors reported.
The study is published in Graefe's Archive for Clinical and Investigative Ophthalmology.