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Study: In situ excision for donor cornea retrieval is viable

Cornea. 2008;27(10):1103-1108.

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The biological and functional quality of corneal grafts obtained by two techniques of donor corneal harvesting — whole globe enucleation and in situ excision — are comparable.

In a prospective, comparative study, donor corneal tissue was retrieved by enucleation in 50 cases and by in situ excision in 50 cases. Endothelial cell counts, ultrasonic corneal pachymetry, microbial contamination, graft clarity and postoperative medial visual acuity at 3 months were evaluated.

At 3 months, the mean postoperative endothelial cell counts were comparable, and 98% of whole globe corneas and 92% of in situ grafts had graft clarity of 3+ or greater. Graft infection developed in two cases in the in situ group and in no cases in the whole globe group.

The authors said that in situ excision is a viable alternative to whole globe enucleation, especially in countries where shortages of donor corneas are common.