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Study identifies risk factors for endophthalmitis among patients with Klebsiella sepsis
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Among patients with Klebsiella sepsis, liver abscess and disseminated intravascular coagulation may be risk factors for endogenous endophthalmitis, according to a retrospective study published in the May issue of British Journal of Ophthalmology.
To identify risk factors for Klebsiella endophthalmitis, Chelvin CA Sng, MD, and colleagues analyzed 133 patients with positive blood cultures for Klebsiella bacteremia admitted to Changi General Hospital, Singapore, between August 2004 and July 2005. Potential risk factors included age, sex, race and total white cell count at presentation. In addition, the investigators evaluated maximum temperature response, co-morbid pathologies, presence of severe infection, site of primary infection, antibiotic sensitivity of the bacterial strain and systemic antibiotics treatment regimens.
Of these 133 patients, five (3.8%) developed endophthalmitis, the authors noted.
Both univariate and multivariate analysis showed that Klebsiella endophthalmitis was significantly associated with liver abscess as the primary site of infection (P < .001) and disseminated intravascular coagulation (P = .01).
Diabetes mellitus and other co-morbid pathologies, as well as race and maximum temperature response, were not identified as risk factors for the occurrence of endophthalmitis, according to the study.