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Study identifies microbial spectrum linked to endophthalmitis post-PK

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FORT LAUDERDALE, Fla. — A high-incidence of gram-positive species, most notably Streptococcus, is associated with post-penetrating keratoplasty endophthalmitis, according to a study presented here.

At the annual meeting of the Association for Research in Vision and Ophthalmology, authors said this is one of the largest, single-center series on microbial susceptibilities in post-penetrating keratoplasty (PK) endophthalmitis.

D.Y. Kunimoto and other retinal specialists from Wills Eye Hospital reviewed 1,074 cases of endophthalmitis presenting between 1989 and 2000. They then examined vitreous biopsy isolates from 14 patients identified with endophthalmitis stemming from PK.

Of the 13 organism-inducing cases of endopthalmitis, 11 were culture-positive and the remaining two had organisms viewed on pathology specimen.

The microbial spectrum included 10 gram-positive cocci and three gram-negative organisms, according to the study. The authors also reported that the patients were susceptible to organism-appropriate antibiotics, including cefazolin, ciprofloxacin, nafcillin and vancomycin.